Curriculum Vitae
John H. Sirak, MD
Division of Cardiothoracic Surgery
Ohio State University
N-820 Doan Hall
410 W. 10th Ave.
Columbus, OH 43210
(614) 366-7414
APPOINTMENTS:
2004-Present: Clinical Assistant Professor of Surgery, Ohio State University Medical Center
2003-04: Clinical Associate, Department of Cardiovascular Surgeery, Cleveland Clinic Foundation
EDUCATION:
2002-03: Minimally Invasive Cardiac Surgery Fellowship, Ohio State University, Columbus, OH
2000-02: Cardiothoracic Surgery Residency, Ohio State University, Columbus, OH
1997-00: General Surgery Residency, Ohio State University, Columbus, OH
1991-05: General Surgery Residency, University of California, Davis - East Bay, Oakland, CA
1987-91: Case Western Reserve University, Cleveland, OH, Degree: Medical Doctor
1985-87: Post-Baccalaureate Premedical Education Program, Bryn Mawr University, Bryn Mawr, PA
1980-85: Amherst College, Amherst, MA, Degree: B.A. cum laude in Political Science
CURRENT RESEARCH:
2008-Present: Principal Investigator, Minimally Invasive Surgical Therapy of Atrial Fibrillation (Single Center Observational)
2008-Present: Co-Investigator, Epicardial vs. Percutaneous Therapy of Atrial Fibrillation (Single Center Randomized Controlled Trial)
PREVIOUS RESEARCH:
2007: Principal Investigator, Shelhigh Valve Implantation Study (Multi-Center Observational)
1995-97: Post-Doctoral Research Fellow, Charles Orosz, PhD, Department of Surgery, Division of Transplantation, Ohio State University (Delayed-type hypersensitivity as an index of allosensitization in murine heterotopic heart transplant recipients)
CERTIFICATIONS:
5/08: Diplomate, American Board of Surgery, Certificate no. 53485
JOURNAL AD HOC REVIEWER:
Annals of Thoracic Surgery
PROFESSIONAL SERVICES:
2006-Present: Consultant, Atricure, Inc., Cincinnati, OH
PUBLICATIONS:
Sirak JH, Orosz CG, Wakely E, VanBuskirk AM. Alloreactive delayed-type hypersensitivity in graft recipients: Complexity of responses and divergence from acute rejection. Transplantation 63(9): 1300-1307, 1997.
VanBuskirk AM, Wakely ME, Sirak JH, Orosz CG. Patterns of allosensitization in allograft recipients. Long-term cardiac allograft acceptance is associated with active alloantibody production in conjunction with active inhibition of alloreactive delayed-type hypersensitivity. Transplantation 65(8): 1115-1123, 1998.
Sirak JH, Orosz CG, Roopenian DC, Wakely E, VanBuskirk AM. Cardiac allograft tolerance. Failure to develop in interleukin-4-deficient mice correlates with unusual allosensitization patterns. Transplantation 65(10): 1352-1356, 1998.
VanBuskirk A, Sirak J, Wakely E, Orosz CG. Patterns of cellular and humoral allosensitization in allograft tolerance vs. rejection. Presented to: Tolerance Induction Symposium, Jan 19-22, 1997.
Orosz CG, Wakely E, Sirak JH, VanBuskirk AM. Is there a final common pathway of tolerance maintenance in immunosuppressed cardiac allograft recipients. Presented to: Tolerance induction Symposium, Jan 19-22, 1997.
Sirak J, Wakely E, Orosz CG, VanBuskirk A. Allograft-tolerant splenocytes mediate alloantigen-dependent active interference of DTH responses. Presented to: Tolerance Induction Symposium, Jan 19-22, 1997.
VanBuskirk AM, Pelletier RP, Sirak JH, Wakely E, Orosz CG. Desirable vs. undesirable patterns of post-transplant allosensitization. Presented to: The American Society of Transplant Physicians 16th Annual Scientific Meeting, May 10-14, 1997.
Pelletier RP, VanBuskirk AM, Sirak JH, Wakely ME, Orosz CG. Are there desirable patterns of post-transplant allosensitization? Presented to: Fifth Basic Sciences Symposium of the Transplantation Society, September 6-11, 1997.
Carrodeguas L, VanBuskirk A, Adams P, Sirak J, Orosz CG. Trans-vivo method for human DTH analysis. Presented to: Fifth Basic Sciences Symposium of the Transplantation Society, September 6-11, 1997.
VanBuskirk AM, Sirak JH, Wakely ME, Orosz CG. Splenocytes from tolerant cardiac allograft recipients can regulate delayed-type hypersensitivity responses and acute allograft rejection. Presented to: Fifth Basic Sciences Symposium of the Transplantation Society, September 641, 1997.
VanBuskirk AM, Wakely ME, Sirak JH, Roopenian DC, Orosz CG. Splenocytes from 1L-4-intact tolerant cardiac allograft recipients, but not IL-4 KO allograft recipients, can regulate delayed-type hypersensitivity and acute allograft rejection. Presented to: 26th Annual Autumn Immunology Conference, November 21-23, 1997.
VanBuskirk A, Sirak J, Roopenian D. Wakely E, Orosz C. 1L-4 KO mice fail to develop long-term allograft survival. Presented to: The American Society of Transplant Physicians, May 9-13, 1998.
VanBuskirk A, Sirak J, Roopenian D, Wakely M, Orosz CG. IL-4 KO mice fail to accept cardiac allografts and generate regulator T cells. Presented: XVII World Congress, The Transplantation Society, July 12-17, 1998.
Sirak J, Gillinov AM, McCarthy P, Blackstone E. Bipolar Radiofrequency Isolation for Treatment of Atrial Fibrillation. Poster presented at the American College of Cardiology, 7 March 2004.
Lozonschi L, Sirak J, Michler, R. Transaortic delivery of the transmitral lesion in a complete cryothermic Maze procedure. Ann Thor Surg 2007;83:1904-5.
Gillinov AM, Sirak J, Blackstone E, McCarthy P, Rajeswaran J, Pettersson G, Sabik F, Svensson L, Navia J, Cosgrove D, Marrouche N, and Natale A. The Cox maze procedure in mitral valve disease: Predictors of recurrent atrial fibrillation. J. Thorac. Cardiovasc. Surg., Dec 2005; 130: 1653 - 1660.
Dzwonczyk R, del Rio C, Sai-Sudhakar C, Sirak J, Michler R, Sun B, Kelbick N, Howie M. Vacuum-assisted apical suction devices induce passive electrical changes consistent with myocardial ischemia during off-pump coronary artery bypass graft surgery. Eur. J. Cardiothorac. Surg., Dec 2006; 30: 873 - 876.
Firstenberg M, Sai-Sudhakar C, Sirak J, Crestanello J, Sun B. Intestinal ischemia complicating ascending aortic dissection: first things first. Ann Thorac Surg, 2007(84): e8-e9.
Firstenberg M, Crestanello J, Sai-Sudhakar C, Sirak J, Sun B. Ascending aortic dissection: look again before you leap. Ann Thorac Surg, 2008(85): 1782-84.
Sirak J, Jones D, Sun B, Sai-Sudhakar S, Crestanello J, Firstenberg M. Toward a definitive, totally thoracoscopic procedure for atrial fibrillation. Ann Thorac Surg, 2008(86): 1960-64.
Sirak, J, Jones D, Sun B, Sai-Sudhakar S, Crestanello J, Firstenberg M. Toward a definitive, five-box thoracoscopic procedure for atrial fibrillation. Poster accepted for the AHA annual meeting, November 2008.
PRESENTATIONS/CME:
Sirak, J. Atrial Fibrillation Surgery. Ohio State University Continuing Medical Education Live Webcast, 11 August 2004.
Sirak, J. New Therapies for Atrial Fibrillation. Ohio State University Department of Surgery Grand Rounds Presentation, 30 September 2004.
Sirak, J. Minimal Access Cardiac Surgery: New Strategies in the Treatment of Valvular Heart Disease and Atrial Fibrillation. Ohio State University Department of Internal Medicine Grand Rounds Presentation, 4 November 2004.
Sirak, J. Symposium Course Director for New Strategies in the Management of Atrial Fibrillation, Ohio State University, 6 May 2005.
Sirak, J. New Developments in the Therapy for Atrial Fibrillation. Ohio State University Heart Failure at the Shoe, March 2006.
Sirak, J. Symposium Course Director for New Strategies in the Management of Atrial Fibrillation, Ohio State University, August, 2006.
Sirak, J. Update in the Surgical Management of Atrial Fibrillation, St. John Macomb Hospital, 30 September 2006.
Sirak, J. Surgical Management of Lone Atrial Fibrillation, Southeastern Ohio Regional Medical Center, 25 October 2006.
Sirak, J. Surgical Management of Lone Atrial Fibrillation, Genesis Health System/Bethesda Hospital, Zanesville, OH, 7 February 2007.
Sirak, J. Surgical Options in the Management of Atrial Fibrillation, OSU Heart Month Presentation, Ohio State University Ross Heart Hospital, 28 February 2007.
Sirak, J Current Strategies in the Surgical Management of Atrial Fibrillation, OSU Heart Month Presentation, Ohio State University Ross Heart Hospital Presentation, 20 March 2007.
Sirak, J. A Totally Thoracoscopic Approach to the MiniMaze Procedure. AATS, May 2007.
Sirak, J. Advances in Treatment of Atrial Fibrillation: New Surgical Techniques Presentation for Ohio Thoracic & Cardiovascular Data Management Group, Ohio State University, 24 October 2007.
Sirak, J. Atrial Fibrillation Ablation: Burn or Cut? Heart Failure at the Shoe, Ohio State University, 9 November 2007.
Sirak, J. New Surgical Perspectives on Atrial Fibrillation. Akron General Hospital 20th Annual Cardiovascular Invitational. Akron General Hospital, Akron, OH July 2008.
Sirak, J. Surgery for Atrial Fibrillation: When Is This Appropriate? IMAGINE Conference, Ohio State University, 24 October 2008.